20 jobs found with Ultragenyx a company that value diversity

Why Join Us? Be a hero for our rare disease patients At Ultragenyx, we fundamentally believe that taking real impactful action to care for the needs of patients and our people is always the right thing to do. To achieve this goal, our vision is to lead the future of rare disease medicine. For us, this means going where other biopharma companies won’t go – challenging the status quo and creating a new model that advances our field so more patients and caregivers can benefit from life-changing treatments. We do this by following the science, applying a novel rapid development approach, making innovative medicines at fair and reasonable prices, and creating a collaborative ecosystem to reach patients in ways that are most meaningful for them. Our commitment and care for patients extends to our people, so culture is an essential cornerstone for Ultragenyx. We remain continuously focused on creating a supportive and inclusive environment of profound learning and growth – so employees can thrive in all areas of their lives, in and outside of work. Ultimately, we want to be an organization where we would be proud for our family, friends and children to work. If you want to have a meaningful impact, do the best work of your career, and grow a lot, both professionally and personally, come join our team.

Position Summary:

As a Senior Scientist in DMPK at Ultragenyx, you will be part of the preclinical translational science team that efficiently advances rare disease drug pipeline from preclinical studies through clinical development. You will have the opportunity to work on diverse drug modalities (AAV, oligonucleotide, small molecules, biologics) and will be responsible for characterization of their ADME, PK, and PK/PD properties to support preclinical development programs and clinical translation. You will be empowered to serve as a DMPK representative in project teams to provide data interpretation and engage in strategic decision-making discussions. In addition, you will actively contribute to the preparation of nonclinical documents for regulatory filings and interactions.

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Work Model:

Flex: This role will typically require onsite work 2-3 days each week, or more depending on business needs. In many locations, the business will set certain days each week that Flex employees are required to be onsite.

Responsibilities:

Evaluate the ADME properties of investigational therapeutics in pre-clinical species to guide candidate selection for clinical development

Design, analyze, and interpret PK and PK/PD studies and data in pre-clinical species through internal and external collaborations

Integrate pre-clinical DMPK/pharmacology data to characterize PK/PD relationships of drug candidates

Utilize integrated preclinical data to provide first-in-human dose recommendations for different drug modalities and disease indications

Serve as the DMPK representative on cross-functional project teams and actively contribute to strategic discussions on the development of preclinical drug candidates

Author and review ADME sections of study reports, nonclinical study protocols, and regulatory documents

Maintain a current understanding of DMPK literature and methodology, as well as scientific literature related to specific drug development projects

Requirements:

PhD or equivalent degree in pharmacology, pharmaceutical science, molecular biology, or a related field and at least 5-8 years of relevant industry experience in DMPK

Strong knowledge of in vitro and in vivo DMPK assays and bioanalytical methods to evaluate ADME properties of drug candidates

Proficiency in hands-on PK NCA analysis and data reporting using Phoenix WinNonlin. Experience with PK/PD modeling is preferred.

Excellent communication (oral and written), organizational, and interpersonal skills

Familiar with regulatory requirements and experience supporting regulatory filings with contributions to ADME sections of regulatory documents

Demonstrated ability to work independently and lead cross-functional collaborations

Experience with diverse drug modalities (e.g., small molecules, biologics, oligonucleotides) is preferred.

Experience in performing cell-based molecular assays is preferred.

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Full Time employees across the globe enjoy a range of benefits, including, but not limited to: · Generous vacation time and public holidays observed by the company · Volunteer days · Long term incentive and Employee stock purchase plans or equivalent offerings · Employee wellbeing benefits · Fitness reimbursement · Tuition sponsoring · Professional development plans * Benefits vary by region and country

Ultragenyx Pharmaceutical is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital and veteran status, and any other status or classification protected by applicable federal, state, and/or local laws. Reasonable accommodation will be provided for all protected statuses or classifications protected by applicable law, including individuals with disabilities, disabled veterans, for pregnancy, childbirth, and related medical conditions, and based on sincerely held religious beliefs. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, you may contact Talent Acquisition by emailing us at talentacquisition@ultragenyx.com.

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