Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Role Overview

Legend Biotech is an international commercial stage biopharmaceutical company focused on the discovery and development of novel cell therapies for oncology and autoimmune disease (AID) indications. We are seeking a Senior Scientist who will contribute to our growing pipeline of innovative cell therapy in AID area. Expertise in immunology and/or AID/oncology is required. The ideal candidate will be a highly motivated individual who enjoys fast paced biotech environment. You will thrive in a collaborative work environment and gain skillsets in advancing multiple projects concurrently. Knowledge of state-of-art immunotherapy and its applications. As part of the Legend Biotech R&D team and under minimal supervision, you will be responsible for timely execution and delivery of projects in our discovery pipelines.

Key Responsibilities

• Isolate immune cells from leukopak or blood samples from healthy donors or patients, activation/expand immune cells and measure phenotypes through assays, such as multiple color flow cytometry, and perform functional assays including but not limited to cytotoxicity and cytokine secretion.
• Virus genome engineering; package and characterize engineered virus particles with molecular assays; measure transduction rate using flowcytometry and conduct VCN analysis.
• Develop and optimize immunoassays to detect host immune response to the virus particles, including neutralization activities.
• Conduct functional analysis of immune cells transduced in vitro and in vivo; perform experiments to examine the persistence of CAR-T cells in vitro and in vivo.
• Deliver experiment results to meet timeline with accountability.
• Prepare and present reports, publications, presentations and patent application documents.
• Keep accurate laboratory documentation, especially electronic lab notebook.
• Maintain compliance with GLP and EHS protocols
• Present results in small team and large functional group meetings.

Requirements

• Ph. D. in immunology, oncology or related fields.
• 3-5 years of experience in the field of cell therapy, immunology, self-replicating virology or AID.
• Experience with in vivo CAR-T and/or deep understanding of AID.
  
• Extensive experience in cellular and immune cell-based analytics and assay development, including but not limited to, advanced multi-parameter flow-cytometry, immunogenicity assay such as mixed lymphocyte reaction assay, cytotoxicity assay, cytokine release measurement using ELISA/MSD multiplex assay.
• Extensive experience of lentivirus or self-replicating RNA engineering, packaging, tittering and related delivery methods and characterization assays.
• Experience of in vivo tissue/cell-specific gene delivery in animal models is a plus.
• Genome editing experience is a plus.
• Strong hands-on skills and a critical thinker with strong problem-solving skills.
• Up-to-date knowledge of immunology, immunotherapy, self-replicating virology and AID.
• Track record of productivity evidenced by publications or patents.
• Independently plan and timely execution of research programs.
• Excellent oral and written communication skills.
• A team player who can work efficiently as an individual.

#Li-JR1

#Li-Onsite

The anticipated base pay range for this is: $123,605 - $169,958 USD.

Benefits:

We are committed to creating a workplace where employees can thrive - both professionally and personally. To attract and retain top talent in a highly competitive industry, we offer a best-in-class benefits package that supports well-being, financial stability, and long-term career growth. Our offerings are designed to meet the diverse needs of our team members and their families, ensuring they feel valued and supported every step of the way. Highlights include medical, dental, and vision insurance as well as a 401(k)-retirement plan with company match that vest fully on day one. Equity and stock options are available to employees in eligible roles, we offer eight weeks of paid parental leave after just three months of employment, and a paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs - demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.

EEO Statement

Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions.

Legend Biotech maintains a drug-free workplace.