Job Description

About This Role

The Senior Scientist role in the Biotherapeutics Discovery and Delivery group within BioDesign will collaborate closely with CROs and external partners to deliver high-quality therapeutic candidates efficiently. Leveraging expertise in antibody engineering principles, structure, and characterization, you will strategically guide antibody discovery and optimization. This role also involves designing and developing antibody-oligonucleotide and protein fusion therapeutics, utilizing machine learning techniques for hit triage, lead optimization, and identification of sequence liabilities. Extensive cross-functional collaboration is essential for advancing novel antibody therapeutics into the pipeline. Your strategic vision, innovation focus, and effective execution will significantly impact Biogen's biologics capabilities.

What You'll Do

Manage external antibody discovery through CROs and collaborative partnerships
Strategically apply antibody engineering and optimization approaches
Conduct antibody developability assessments
Collaborate with internal and external partners with machine learning expertise to apply ML strategies for hit triage, lead optimization, and identifying sequence liabilities
Design and develop antibody-oligonucleotide and protein fusion therapeutics
Oversee project timelines and deliverables to ensure high-quality therapeutic antibody candidates
Lead cross-functional teams to integrate antibody discoveries into pipeline programs
Identify and implement strategic innovations within antibody discovery and engineering
Interpret and oversee analysis of single-cell technology data (e.g., 10x Genomics)
Maintain clear, effective communication with internal stakeholders and external collaborators
Ensure thorough antibody characterization and rigorous quality control

Who You Are

You are a strategic thinker with deep expertise in antibody structure, engineering, and characterization, passionate about collaborating externally and driving therapeutic innovations. You excel in cross-functional leadership and have a proven track record of advancing complex biologics from discovery to the pipeline.

Qualifications

Required Skills

Ph.D. in biochemistry, chemical biology, or a related field with 2-5 years experience, or a Master's degree with 6-8 years relevant industry experience.

Proven experience managing antibody discovery through external partnerships (CROs)

Deep expertise in antibody developability assessment and engineering
Proficiency with machine learning methods for antibody optimization, hit triage, and sequence liability evaluation
Experience in designing antibody-oligonucleotide or protein fusion therapeutics
Strong project management skills for delivering high-quality candidates on schedule
Excellent communication skills for effective collaboration internally and externally
Broad knowledge of antibody applications in therapeutic pipeline development

Preferred Skills

Experience with single-cell technologies (10x Genomics) and/or display platforms (yeast).
Familiarity with biologics data management and integration platforms

Experience developing complex biologics such as bispecific antibodies, fusion proteins, or engineered scaffolds.

Additional Information

The base salary range for this position is $122,000 - $163,000. Base salary offered is determined though an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity. Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.

In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees and their families' physical, financial, emotional, and social well-being; including, but not limited to:

Medical, Dental, Vision, & Life insurances
Fitness & Wellness programs including a fitness reimbursement
Short- and Long-Term Disability insurance
A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
Up to 12 company paid holidays + 3 days off for Personal Significance
80 hours of sick time per calendar year
Paid Maternity and Parental Leave benefit
401(k) program participation with company matched contributions
Employee stock purchase plan
Tuition reimbursement of up to $10,000 per calendar year
Employee Resource Groups participation

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.